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DMT1 blocker 2

CAS No. 1062648-63-8

DMT1 blocker 2( —— )

Catalog No. M23267 CAS No. 1062648-63-8

DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DMT1 blocker 2
  • Note
    Research use only, not for human use.
  • Brief Description
    DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83.
  • Description
    DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks Dosage:50 mg/kg Administration:Oral gavage followed 1 h later by an iron challenge Result:Attenuated the post-challenge serum iron increase.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DMT1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1062648-63-8
  • Formula Weight
    263.29
  • Molecular Formula
    C16H13N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:48 mg/mL?(182.3 mM;?Need ultrasonic)
  • SMILES
    OC1=C2C3=CC=CC=C3CCC2=NN1C4=NC=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cadieux JA, et al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5.
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